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Sleep Better Than Melatonin? Agomelatine – A Melatonin Alternative (Research) [Video]

Sleep Better Than Melatonin? Agomelatine – A Melatonin Alternative (Research)

Sleep Better Than Melatonin? Agomelatine – A Melatonin Alternative (Research)

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Agomelatine is an antidepressant which was first approved in Europe in 2009 [11]. Its main mechanism of action includes agonist at melatonergic (MT1 and MT2) receptors and antagonist at serotonergic 5-HT2C receptor. Animal studies including Vogel conflict procedure, elevated plus-maze procedure, conditioned footshock-induced ultrasonic vocalizations test, social defeat stress test, predator stress test, and the fear learning process suggested anxiolytic properties of agomelatine [12-14]. Studies further showed that agomelatine’s anxiolytic property is mainly attributed from its 5-HT2C antagonism, but melatonin receptor may also be involved in decreasing anxiety [15]. In line with animal models, a study initially showed that agomelatine was effective in treating anxiety symptoms associated with depression [16]. Therefore, numerous randomized, double-blinded, placebo-controlled clinical trials (RCTs) demonstrated that agomelatine could be an effective and safe treatment option for patients with GAD [17,18].
Antidepressants are widely used in the treatment of MDD. In addition, antidepressants have several effects on sleep: in short-term treatment, many activating antidepressant effects may disrupt sleep, while others with sedative properties rapidly improve sleep; however, all antidepressants should normalize sleep in the long-term treatment.13 Agomelatine, as a novel antidepressant for the treatment of MDD, could quickly improve the disturbed sleep-wake cycles,14 sleep efficiency, and correcting the circadian rhythm abnormalities,15 with a promising role for the treatment of sleep disorders associated with MDD.16 In addition, the melatonin (MT) receptor agonists are now appearing as the new promising treatment options for sleep and circadian-rhythm-related disorders, such as agomelatine and ramelteon.17 Being the MT1 and MT2 receptors agonists, agomelatine is also an antagonist that affects the 5-hydroxytryptamine-2C (5HT2c) receptors. Since agomelatine acts on the suprachiasmatic nucleus, hippocampus, frontal cortex, and the striatum, it could lead to the improvement of both the sleep and mood.18,19 There are distinctive differential binding affinities to MT1 versus MT2: Agomelatine binds to MT1 and MT2 receptors with approximately equal affinity and additional antagonist properties at the 5‐HT2c receptors, and ramelteon exhibits a 10‐fold greater affinity for MT1 than MT2.20,21 This might explain why there are differences in the effect of facilitations in sleep-onset between these two medications. However, problems of the sleep-wake cycle and circadian rhythm would be corrected by the usage of agomelatine.15,16 However, there has been little research done on the association between agomelatine and the usage of sedative-hypnotics. This study aimed to test the hypothesis as to whether being treated with agomelatine is less likely to be co-treated with sedative hypnotic agents. Reference: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384877/

DISCLAIMER: The information provided in this video is for entertainment purposes only and IS NOT MEDICAL ADVICE. If you have questions about your health contact a medical professional.This content is strictly the opinion of Lucas Aoun and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Lucas Aoun nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.

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Better Sleep

Dr. Gominak - Anxiety, Depression, Sleep Disorders AND MORE Due to a Lack of Vitamins D and B [Video]

Dr. Gominak - Anxiety, Depression,The World Epidemic of Sleep Disorders AND MORE Due to a Lack of Vitamins D and BImagine a world filled with people pain-free with mental illness, anxiety, depression and psychosis a thing of the past. Medical illness is reduced. Medication use is minimized. Dr. Gominak believes, “See your doctor once a year, heal your body every night. The world epidemic of sleep disorders AND MORE is linked to Vitamin D deficiency!Dr. Gominak also says that autism is linked to insufficient deep sleep.The global struggle with worsening sleep is linked to reduced sun exposure, says Dr. Gominak.See your doctor once a year. Heal your body every night.Given back enough time in deep sleep and the necessary raw materials (D and B vitamins) the brain can make up for the deep sleep that it missed and develop normal social skills even into the teens and early 20’s.Not a morning person? Dr. Gominak says that’s due to a sleep disorder.Follow Dr. Gominak athttps://drgominak.com/Follow Dr. J atwww.educationalimpactacademy.comTwitter - @karinjakubowskihttps://twitter.com/KarinJakubowskiInstagram - #jakubowskikarinhttps://www.instagram.com/jakubowskikarin/?scrlybrkr=aa6443f3

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Better Sleep

Ambient Sleep Music ★︎ Stronger Immune System ★︎ Melatonin Release, Deep Sleep MusicWe create ambient new age music intended to help you sleep more easily. This music can also be used for study, spa, meditation, stress relief, sleep & relaxation. To view our complete collection visit our home page https://www.youtube.com/silentrhythm. Where you will find a playlist of your choice.🎵Track information:Title: Deep Sleep 05 Composed by SilentRhythmTry Listening with your headphones in a quiet environment for the best results.Thank you for watching and I hope this video helps you. Namaste 🙏 🎧 We recommend using your headphones while listening to this music.#FallAsleepFast #AmbientSleepMusic #Meditate© Copyright:Any reproduction or republication of all or part of this video/audio is prohibited.Music composed by SilentRhythmFootage Licensed to SilentRhythm (Envato)Copyright ⓒ2021 SilentRhythm®. All Rights Reserved

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