Recent research shows that a natural herbal compound reduces senescence and intervertebral disc degeneration in mice.
Intervertebral discs are shock-absorbing tissues located between our vertebral bones that allow the spine to bend. They degrade with age, leading to complaints such as back pain, degenerative disc disease, and herniated discs.
Based on the hypothesis that an inflammatory response to cellular senescence is to blame for disc degeneration, researchers investigated whether the anti-inflammatory dehydrocostus lactone (DHE) could help.
They tested the effect of DHE on cells from the gel-like region at the center of the discs, which are known to contribute to local inflammation. While high doses proved cytotoxic, they found that low doses were beneficial. DHE reduced the inflammatory response when the cells were exposed to an inflammatory cytokine.
They also tested DHE in a mouse model of spinal instability. DHE-treated mice had better spinal structure and less inflammation.
While DHE reduced inflammation, the team did not measure whether it affected senescence. Though more research will be needed to clarify this, the anti-inflammatory effect alone warrants consideration as a potential treatment for disc degradation.
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#DHE #aging #inflammation #senescence